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http://hdl.handle.net/123456789/5106| Title: | A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge |
| Authors: | Seidu-Larry, Salifu Krieg, Bettina Hirsch, Markus Helm, Mark Domingo, Olwen |
| Issue Date: | 2012 |
| Publisher: | University of Cape Coast |
| Abstract: | A propargyl containing guanosine phosphonamidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity |
| Description: | 4p:, ill. |
| URI: | http://hdl.handle.net/123456789/5106 |
| ISSN: | 23105496 |
| Appears in Collections: | Department of Biochemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A modified guanosine phosphoramidite for click functionalization of.pdf | Article | 1.97 MB | Adobe PDF | View/Open |
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