Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5106
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dc.contributor.authorSeidu-Larry, Salifu-
dc.contributor.authorKrieg, Bettina-
dc.contributor.authorHirsch, Markus-
dc.contributor.authorHelm, Mark-
dc.contributor.authorDomingo, Olwen-
dc.date.accessioned2021-03-22T18:44:46Z-
dc.date.available2021-03-22T18:44:46Z-
dc.date.issued2012-
dc.identifier.issn23105496-
dc.identifier.urihttp://hdl.handle.net/123456789/5106-
dc.description4p:, ill.en_US
dc.description.abstractA propargyl containing guanosine phosphonamidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activityen_US
dc.language.isoenen_US
dc.publisherUniversity of Cape Coasten_US
dc.titleA modified guanosine phosphoramidite for click functionalization of RNA on the sugar edgeen_US
dc.typeArticleen_US
Appears in Collections:Department of Biochemistry

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