Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5533
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dc.contributor.authorLu, Hongxiang-
dc.contributor.authorChen, Rong-
dc.contributor.authorBarnie, Prince Amoah-
dc.contributor.authorTian, Yu-
dc.contributor.authorZhang, Shiqing-
dc.contributor.authorXu, Huaxi-
dc.contributor.authorChakrabarti, Subrata-
dc.contributor.authorSu, Zhaoliang-
dc.date.accessioned2021-06-28T11:31:04Z-
dc.date.available2021-06-28T11:31:04Z-
dc.date.issued2020-
dc.identifier.issn23105496-
dc.identifier.urihttp://hdl.handle.net/123456789/5533-
dc.description14p:, ill.en_US
dc.description.abstractResident cardiac macrophages play important roles in homeostasis, maintenance of cardiac function, and tissue repair. After cardiac injury, monocytes infiltrate the tissue, undergo phenotypic and functional changes, and are involved in inflammatory injury and functional remodeling. However, the fate of cardiac infiltrating/polarized macrophages and the relationship between these cells and resident cardiac macrophage replenishment following injury remain unclear. Our results showed that angiotensin II induces cardiac fibroblast transdifferentiation into cardiac myofibroblasts (MFBs). In cocultures with MFBs and murine macrophages, the MFBs promoted macrophage polarization to M1 phenotype, followed by selective apoptosis, which was associated with TNF/TNFR1 axis and independent of NO production. Surprisingly, after 36 h of coculture, the surviving macrophages were converted to M2 phenotype and settled in heart, which was dependent on leptin produced by MFBs or polarized macrophages ia the PI3K or Akt pathway. CCR2+CD45.2+ cells adoptively transferred into CD45.1+ mice with viral myocarditis, differentiated into CD45.2+CCR2+CX3CR1+ M2 cells during the resolution of inflammation and settled within the heart. Our data highlight a novel mechanism related to the renewal or replenishment of cardiac resident macrophages following cardiac injury; and suggest that trans differentiation of cardiac fibroblasts may promote the resolution of inflammationen_US
dc.language.isoenen_US
dc.publisherUniversity of Cape Coasten_US
dc.subjectCardiac injuryen_US
dc.subjectCardiac resident macrophageen_US
dc.subjectInflammationen_US
dc.subjectLeptinen_US
dc.subjectTrans differentiationen_US
dc.titleFibroblast transdifferentiation promotes conversion of M1 macrophages and replenishment of cardiac resident macrophages following cardiac injury in miceen_US
dc.typeArticleen_US
Appears in Collections:Department of Biomedical & Forensic Sciences

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