University of Cape Coast Institutional Repository
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http://hdl.handle.net/123456789/5551| Title: | IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells |
| Authors: | Bie, Qingli Zhang, Bin Sun, Caixia Ji, Xiaoyun Barnie, Prince Amoah Qi, Chen Peng, Jingjing Zhang, Danyi Zheng, Dong Zheng, Dong Su, Zhaoliang Wang, Shengjun Xu, Huaxi |
| Keywords: | Gastric cancer IL-17B, mesenchymal stem cells (MSCs) Stemness |
| Issue Date: | 27-Jan-2017 |
| Publisher: | University of Cape Coast |
| Abstract: | Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of IL-17B on mesenchymal stem cells in tumor microenvironment and its impact on the tumor progression. The results showed that IL-17B induced the expression of stemness-related genes Nanog, Sox2, and Oct4 in mesenchymal stem cells and enhanced its tumor-promoting effect. The supernatant from cultured mesenchymal stem cells after treating with exogenous rIL-17B promoted the proliferation and migration of MGC-803, therefor suggesting that rIL-17B might promote mesenchymal stem cells to produce soluble factors. In addition, rIL-17B also activated the NF-κΒ, STAT3, β-catenin pathway in mesenchymal stem cells. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells |
| Description: | 10p:, ill. |
| URI: | http://hdl.handle.net/123456789/5551 |
| ISSN: | 23105496 |
| Appears in Collections: | Department of Biomedical & Forensic Sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IL-17B activated mesenchymal stem cells enhance proliferation.pdf | Article | 7.23 MB | Adobe PDF | View/Open |
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