Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5568
Title: Myeloid‑derived suppressor cells and myeloid regulatory cells in cancer and autoimmune disorders (Review)
Authors: Barnie, Prince Amoah
Zhang, Pan
Lv, Hongxiang
Wang, Dan
Su, Xiaolian
Su, Zhaoliang
Xu, Huaxi
Issue Date: 2015
Publisher: University of Cape Coast
Abstract: Myeloid-derived suppressor cells (MDSCs) were originally described as a heterogeneous population of immature cells derived from myeloid progenitors with immune-suppressive functions in tumor-bearing hosts. In recent years, increasing number of studies has described various populations of myeloid cells with MDSC-like properties in murine models of cancer and autoimmune diseases. These studies have observed that the populations of MDSCs are increased during inflammation and autoimmune conditions. In addition, MDSCs can effectively suppress T cell responses and modulate the activity of natural killer cells and other myeloid cells. MDSCs have also been implicated in the induction of regulatory T cell production. Furthermore, these cells have the potential to suppress the autoimmune response, thereby limiting tissue injury. Myeloid regulatory cells (Mregs) are recently attracting increasing attention, since they function in pro inflammatory and immune suppression in autoimmune diseases, as well as in various types of cancer. Currently, research focus is directed from MDSCs to Mregs in cancer and autoimmune diseases. The present study reviewed the suppressive roles of MDSCs in various autoimmune murine models, the immune modulation of MDSCs to T helper 17 lymphocytes, as well as the pro inflammatory and immunosuppressive roles of Mregs in various types of cancer and autoimmune diseases
Description: 11p:, ill.
URI: http://hdl.handle.net/123456789/5568
ISSN: 23105496
Appears in Collections:Department of Biomedical & Forensic Sciences

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