Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5606
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dc.contributor.authorCaprio, Vittorio-
dc.contributor.authorGuyen, Berengere-
dc.contributor.authorOpoku-Boahen, Yaw-
dc.contributor.authorMann, John-
dc.contributor.authorGowan, Sharon M.-
dc.contributor.authorKelland, Lloyd M.-
dc.contributor.authorReadd, Martin A.-
dc.contributor.authorNeidle, Stephen-
dc.date.accessioned2021-07-07T11:39:41Z-
dc.date.available2021-07-07T11:39:41Z-
dc.date.issued2000-
dc.identifier.issn23105496-
dc.identifier.urihttp://hdl.handle.net/123456789/5606-
dc.description4p:, ill.en_US
dc.description.abstractThe bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesized that the latter activity is due to stabilization of an intermediate guaninquadruplex complex, in accordance with computer modellingen_US
dc.language.isoenen_US
dc.publisherUniversity of Cape Coasten_US
dc.titleA novel inhibitor of human telomerase derived from 10h-indolo[3,2-b]quinolineen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

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