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http://hdl.handle.net/123456789/5606| Title: | A novel inhibitor of human telomerase derived from 10h-indolo[3,2-b]quinoline |
| Authors: | Caprio, Vittorio Guyen, Berengere Opoku-Boahen, Yaw Mann, John Gowan, Sharon M. Kelland, Lloyd M. Readd, Martin A. Neidle, Stephen |
| Issue Date: | 2000 |
| Publisher: | University of Cape Coast |
| Abstract: | The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesized that the latter activity is due to stabilization of an intermediate guaninquadruplex complex, in accordance with computer modelling |
| Description: | 4p:, ill. |
| URI: | http://hdl.handle.net/123456789/5606 |
| ISSN: | 23105496 |
| Appears in Collections: | Department of Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A novel inhibitor of human telomerase derived from 10H-indolo [3, 2-b] quinoline.pdf | Article | 325.96 kB | Adobe PDF | View/Open |
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