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http://hdl.handle.net/123456789/6065| Title: | Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD) |
| Authors: | Adjabui, Michael J. Howard, Nathaniel K. Luguterah, Albert 2017 |
| Keywords: | Maximum safe dose Partitioning principle Distribution-free endpoint Family wise error rate Confidence set |
| Issue Date: | 21-Sep-2017 |
| Publisher: | University of Cape Coast |
| Abstract: | In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose |
| Description: | 12p:, ill. |
| URI: | http://hdl.handle.net/123456789/6065 |
| ISSN: | 23105496 |
| Appears in Collections: | Department of Mathematics & Statistics |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nonparametric Stepwise Procedure for Identification of.pdf | Article | 305.82 kB | Adobe PDF | View/Open |
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