Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6065
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dc.contributor.authorAdjabui, Michael J.-
dc.contributor.authorHoward, Nathaniel K.-
dc.contributor.authorLuguterah, Albert 2017-
dc.date.accessioned2021-09-08T11:00:06Z-
dc.date.available2021-09-08T11:00:06Z-
dc.date.issued2017-09-21-
dc.identifier.issn23105496-
dc.identifier.urihttp://hdl.handle.net/123456789/6065-
dc.description12p:, ill.en_US
dc.description.abstractIn this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purposeen_US
dc.language.isoenen_US
dc.publisherUniversity of Cape Coasten_US
dc.subjectMaximum safe doseen_US
dc.subjectPartitioning principleen_US
dc.subjectDistribution-free endpointen_US
dc.subjectFamily wise error rateen_US
dc.subjectConfidence seten_US
dc.titleNonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)en_US
dc.typeArticleen_US
Appears in Collections:Department of Mathematics & Statistics

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