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DC Field | Value | Language |
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dc.contributor.author | Asare-Anane, Henry | - |
dc.contributor.author | Botchey, Collins Paa Kwesi | - |
dc.contributor.author | Ofori, Emmanuel Kwaku | - |
dc.contributor.author | Boamah, Isaac | - |
dc.contributor.author | Crabbe, Sandra | - |
dc.contributor.author | Asamoah-Kusi, Kwadwo | - |
dc.date.accessioned | 2022-06-15T12:22:23Z | - |
dc.date.available | 2022-06-15T12:22:23Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 23105496 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/8355 | - |
dc.description | 5p:, ill. | en_US |
dc.description.abstract | Objectives: Elevated immunoglobulin levels have been strongly linked to the development and progression of inflammatory disorders such as type 2 diabetes and obesity. This study aimed to evaluate circulating immunoglobulin levels and to identify other metabolic factors that influence humoral immune response among Ghanaian subjects with type 2 diabetes. Methods: A comparative cross-sectional study conducted at the National Diabetes Management and Research Center, Accra. Eighty persons with type 2 diabetes were age-matched with 78 controls. Immunoglobulin A, immunoglobulin G and immunoglobulin M; interleukin 6; fasting blood glucose; glycated hemoglobin; and lipid parameter concentrations were measured. Blood pressure, anthropometry and body composition indices were also assessed. Results: Median immunoglobulin A and immunoglobulin G (g/L) levels were higher in the case group compared with controls (0.89 vs 0.74, p = 0.043; 7.58 vs 7.29, p < 0.001). Immunoglobulin G, immunoglobulin A and interleukin 6 levels in the case cohort, respectively, associated weakly with fasting blood glucose (r = 0.252, p = 0.001; r = 0.170, p = 0.031; r = 0.296, p = 0.001). There were positive correlations within the control group for immunoglobulin A versus interleukin 6 (r = 0.366, p = 0.001) and within the case group for glycated hemoglobin versus interleukin 6 (r = 0.190, p = 0.020). Conclusion: Our data suggest that humoral immune response is altered in subjects with type 2 diabetes and that serum immunoglobulin levels could serve as useful biomarkers in the investigation and management of diabetes mellitus. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Cape Coast | en_US |
dc.subject | Immunoglobulin | en_US |
dc.subject | interleukin | en_US |
dc.subject | type 2 diabetes | en_US |
dc.title | Altered Immunoglobulins (A and G) in Ghanaian Patients with Type 2 Diabetes | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Allied Health Sciences |
Files in This Item:
File | Description | Size | Format | |
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Altered immunoglobulins (A and G) in Ghanaian patients with type 2 diabetes.pdf | Article | 84.14 kB | Adobe PDF | View/Open |
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