Supramolecular Studies into the Co-Crystallization of Ferron with Sulphamethoxazole and Carbazole

Abstract

The mechano-synthesis methods of mixing, grinding and kneading were used to co-crystallize Ferron with Sulphamethoxazole and Ferron with Carbazole. Samples are prepared by mixing with a spatula, grinding for 10, 20 and 30 minutes and kneading for 10,20 and 30 minutes. The starting compounds and the resulting products are characterised using UV/Vis Spectroscopy (UV), Infra-Red Spectroscopy (IR), Powder X-Ray Diffractometry (PXRD), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). Kneading of Ferron with Sulphamethoxazole for 30 minutes yielded a co-crystal with cell parameters: a = 21.00356 A; b = 10.43984 A; c = 28.16611 A; ft = 133.584°; cell volume is 4,473.721 A3 and space group C2/m. Combining Ferron with Carbazole did not yield a co-crystal. The melting point of the combination products of Ferron and Carbazole varies between 208°C and 219°C. When Ferron is mixed or ground with Sulphamethoxazole, the particles of Sulphamethoxazole are found on the surface of the Ferron particles. The same effect is obtained when Ferron is kneaded with Sulphamethoxazole for less than 30 minutes. On the other hand, the particles of Carbazole remain on the surface of the Ferron particles no matter the process applied or its duration.