Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/8956
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBerg, Kelly A.-
dc.contributor.authorPatwardhan, Amol M.-
dc.contributor.authorAkopian, Armen N.-
dc.date.accessioned2023-10-03T17:08:54Z-
dc.date.available2023-10-03T17:08:54Z-
dc.date.issued2012-02-23-
dc.identifier.issn1424-8247-
dc.identifier.urihttp://hdl.handle.net/123456789/8956-
dc.description.abstractRecent discoveries indicate that many G-protein coupled receptors (GPCRs) and channels involved in pain modulation are able to form receptor heteromers. Receptor and channel heteromers often display distinct signaling characteristics, pharmacological properties and physiological function in comparison to monomer/homomer receptor or ion channel counterparts. It may be possible to capitalize on such unique properties to augment therapeutic efficacy while minimizing side effects. For example, drugs specifically targeting heteromers may have greater tissue specificity and analgesic efficacy. This review will focus on current progress in our understanding of roles of heteromeric GPCRs and channels in pain pathways as well as strategies for controlling pain pathways via targeting heteromeric receptors and channels. This approach may be instrumental in the discovery of novel classes of drugs and expand our repertoire of targets for pain pharmacotherapy.en_US
dc.language.isoenen_US
dc.subjectpainen_US
dc.subjectreceptorsen_US
dc.subjectchannelsen_US
dc.subjectsensory neuronsen_US
dc.subjectheteromersen_US
dc.titleReceptor and Channel Heteromers as Pain Targetsen_US
dc.typeArticleen_US
Appears in Collections:School of Allied Health Sciences

Files in This Item:
File Description SizeFormat 
Receptor and Channel Heteromers as Pain Targets.pdfMain Article287.32 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.