Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9116
Title: CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegans by Enteropathogenic Escherichia coli
Authors: Bhatt, Shantanu
Anyanful, Akwasi
Kalman, Daniel
Issue Date: Sep-2011
Publisher: JOURNAL OF BACTERIOLOGY,
Abstract: Enteropathogenic Escherichia coli (EPEC) requires the tnaA-encoded enzyme tryptophanase and its sub- strate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.
URI: http://hdl.handle.net/123456789/9116
Appears in Collections:School of Allied Health Sciences

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