Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9301
Title: A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis
Authors: Antwi-Boasiako, Charles
Andemariam, Biree
Colombatti, Raffaella
Asare, Eugenia Vicky
Strunk, Crawford
Piccone, Connie M.
Manwani, Deepa
Boruchov, Donna
Farooq, Fatimah
Urbonya, Rebekah
Wilson, Samuel
Boatemaa, Gifty Dankwah
Perrotta, Silverio
Sainati, Laura
Rivers, Angela
Rao, Sudha
Zempsky, William
Ekem, Ivy
Sey, Fredericka
Segbefia, Catherine
Inusa, Baba
Tartaglione, Immacolata
Campbell, Andrew D.
Keywords: Leg ulcers
Sickle cell
Hemolysis
International
Issue Date: 2020
Publisher: Annals of Hematology
Abstract: Vasculopathy is a hallmark of sickle cell disease ultimately resulting in chronic end organ damage. Leg ulcer is one of its sequelae, occurring in ~ 5–10% of adult sickle cell patients. The majority of leg ulcer publications to date have emanated from single center cohort studies. As such, there are limited studies on the geographic distribution of leg ulcers and associated risk factors worldwide. The Consortium for the Advancement of Sickle Cell Research (CASiRe) was formed to improve the understanding of the different phenotypes of sickle cell disease patients living in different geographic locations around the world (USA, UK, Italy, Ghana). This cross-sectional cohort sub-study of 659 sickle cell patients aimed to determine the geographic distribution and risk factors associated with leg ulcers. The prevalence of leg ulcers was 10.3% and was associated with older age, SS genotype, male gender, and Ghanaian origin. In fact, the highest prevalence (18.6%) was observed in Ghana. Albuminuria, proteinuria, increased markers of hemolysis (lower hemoglobin, higher total bilirubin), lower oxygen saturation, and lower body mass index were also associated with leg ulceration. Overall, our study identified a predominance of leg ulcers within male hemoglobin SS patients living in sub-Saharan Africa with renal dysfunction and increased hemolysis.
URI: http://hdl.handle.net/123456789/9301
Appears in Collections:School of Medical Sciences

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