Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9534
Title: MISLEADING PRESENTATION OF HAEMOGLOBIN ELECTROPHORESIS DATA
Authors: Adu, Patrick
Simpong, Nicodemus L.
Kontor, Kate
Ephraim, Richrd K.D
Keywords: Electrophoresis,
haemoglobinopathies,
haemoglobin,
cellulose acetate electrophoresis
Issue Date: Mar-2017
Publisher: Ghana Med
Abstract: Haemoglobinopathies are common in sub-Saharan Africa. As such haemoglobin electrophoresis are required to in- form clinical decision making. However, haemoglobin electrophoresis is an assay that detects protein at either alka- line or acidic pH. Such assays do not interrogate gene sequences but rather the product of a gene. As many post- transcriptional and post-translational modifications impact the final output of the gene (i.e. protein), presentation of such protein-based assay must accurately reflect the technique employed. It is grossly misleading and scientifically inaccurate to report cellulose acetate and/or citrate agar haemoglobin electrophoresis results as ‘haemoglobin geno- type’. We propose a new paradigm in which haemoglobin electrophoresis data would be presented as ‘haemoglobin phenotype’ at a specified pH.
URI: http://hdl.handle.net/123456789/9534
Appears in Collections:School of Allied Health Sciences

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