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http://hdl.handle.net/123456789/9560| Title: | APOBEC3G expression and HIV-1 infection in Burkina Faso |
| Authors: | Compaor, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques |
| Keywords: | HIV-1 APOBEC3G mRNA rs8177832 rs35228531 rs6001417 Burkina Faso. |
| Issue Date: | 2018 |
| Publisher: | Journal of Public Health in Africa |
| Abstract: | APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination |
| URI: | http://hdl.handle.net/123456789/9560 |
| Appears in Collections: | School of Medical Sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| APOBEC3G expression and HIV-1 infection in Burkina Faso.pdf | MAIN ARTICLE | 372.97 kB | Adobe PDF | View/Open |
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