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Title: | Anti-nociceptive and antioxidant activities of an aqueous leaf extract of Corchorus olitorius L. (Tiliaceae) |
Authors: | BOYE, A. BARKU, V.Y.A. AMOATENG, P. MBROH, L.A. |
Keywords: | Naloxone glibenclamide morphine nociception DPPH formalin test. |
Issue Date: | Dec-2014 |
Publisher: | International Journal of Biological and Chemical Science |
Abstract: | A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test. COE was screened for its analgesic, and antioxidant activities. The anti-nociceptive effect of COE (3x10-2, 1x10-1 and 3x10-1 g kg-1, p.o), and morphine (1x10-3, 3x10-3 and 1x10-2 gkg-1, i.p.) were evaluated using the formalin-induced nociception test. The study showed that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. COE produced significant (P ˂ 0.05) dose-dependent anti- nociceptive effects similar to morphine in both phases of formalin-induced nociception. The extract showed free radical scavenging properties and different phyto-constituents such as alkaloids, flavonoids, saponins, cardiac glycosides, tannins, anthraquinones and terpenoids were identified. COE has both central and peripheral anti-nociceptive effects mediated through opioidergic receptor activation and also partly through ATP-sensitive K+ channel activation systems. The findings confirms earlier reports, and further shows that C. olitorius produces anti-nociception by interrupting many pain processing pathways. Results further suggest that the extract (COE) might possess some chemical constituents that are responsible for the analgesic and the antioxidant activities. |
URI: | http://hdl.handle.net/123456789/9564 |
ISSN: | 1997-342X 1991-8631 |
Appears in Collections: | School of Allied Health Sciences |
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Anti-nociceptive and antioxidant activities of an aqueous leaf extract of.pdf | Main article | 655.16 kB | Adobe PDF | View/Open |
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