Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/9564
Title: Anti-nociceptive and antioxidant activities of an aqueous leaf extract of Corchorus olitorius L. (Tiliaceae)
Authors: BOYE, A.
BARKU, V.Y.A.
AMOATENG, P.
MBROH, L.A.
Keywords: Naloxone
glibenclamide
morphine
nociception
DPPH
formalin test.
Issue Date: Dec-2014
Publisher: International Journal of Biological and Chemical Science
Abstract: A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test. COE was screened for its analgesic, and antioxidant activities. The anti-nociceptive effect of COE (3x10-2, 1x10-1 and 3x10-1 g kg-1, p.o), and morphine (1x10-3, 3x10-3 and 1x10-2 gkg-1, i.p.) were evaluated using the formalin-induced nociception test. The study showed that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. COE produced significant (P ˂ 0.05) dose-dependent anti- nociceptive effects similar to morphine in both phases of formalin-induced nociception. The extract showed free radical scavenging properties and different phyto-constituents such as alkaloids, flavonoids, saponins, cardiac glycosides, tannins, anthraquinones and terpenoids were identified. COE has both central and peripheral anti-nociceptive effects mediated through opioidergic receptor activation and also partly through ATP-sensitive K+ channel activation systems. The findings confirms earlier reports, and further shows that C. olitorius produces anti-nociception by interrupting many pain processing pathways. Results further suggest that the extract (COE) might possess some chemical constituents that are responsible for the analgesic and the antioxidant activities.
URI: http://hdl.handle.net/123456789/9564
ISSN: 1997-342X
1991-8631
Appears in Collections:School of Allied Health Sciences

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