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http://hdl.handle.net/123456789/9775| Title: | ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF HIPPOCRATEA INDICA ROOT BARK AND POGA OLEOSA FRUITS |
| Authors: | Ogbole, O. O. Ekor, M. N. Oluremi, B. B. Ajaiyeoba, E. O. Gbolade, A. A. Ayoola, M. A. Adeyemi, A. A. |
| Keywords: | Hippocratea indica Poga oleosa Anti-inflammatory antimicrobial |
| Issue Date: | 2007 |
| Publisher: | African Journal of Traditional, Complementary and Alternative Medicines |
| Abstract: | The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants. |
| URI: | http://hdl.handle.net/123456789/9775 |
| ISSN: | 0189-6016©2007 |
| Appears in Collections: | School of Medical Sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF HIPPOCRATEA INDICA ROOT.pdf | MAIN ARTICLE | 91.91 kB | Adobe PDF | View/Open |
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