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Title: Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa
Authors: Ouedraogo, R.A
Zohoncon, T.M
Guigma, S.P
Angèle Traore, I.M
Ouattara, A.K
Ouedraogo, M.
Djigma, F.W
Keywords: High-risk HPV, Real time PCR
Genotypes, Multiple infections, Tenkodogo
Issue Date: Sep-2018
Publisher: Elsevier B.V.
Abstract: Objective: This study was conducted to determine the prevalence and distribution of high-risk human papillomavirus (HR-HPV) genotypes among sexually active women in Tenkodogo, Burkina Faso. Methods: Among 131 sexually active women attending the Tenkodogo Urban Medical Center, endocervical samples were collected prior to screening for precancerous lesions. After viral DNA extraction, fourteen HR-HPV genotypes were characterized by real-time multiplex PCR in these cervical samples. Results: The mean age was 35.5 ± 9.5 years. Of the 131 women, 45 were infected with at least one HR-HPV genotype. The prevalence of HR-HPV infection among these women was 34.4%. Among the 45 oncogenic HPVinfected women, single HR-HPV genotype was found in 55.6% while 44.4% were infected with more than one HR-HPV genotype. The most frequent genotypes were HPV56 (36.5%), HPV66 (36.5%). Conclusion: Tenkodogo women included in this study had a higher prevalence of HPV 56, HPV 66. A larger study with a more representative sample would therefore be needed to determine predominant oncogenic genotypes in the subregion and especially in cancer cases.
Description: Article
ISSN: 2405-8521
Appears in Collections:Department of Molecular Biology & Biotechnology

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